1063Estimating Health Outcomes of Antiviral Use in Influenza (flu) Outbreaks by Linking PK/PD and Epidemiology via Transmission Dynamic Model: A Novel Approach

نویسندگان

  • Patrick Smith
  • Carl Kirkpatrick
  • Craig Rayner
  • Keith Nieforth
  • Georgina Dall
  • Stephen Toovey
  • David Kong
  • David Wu
  • Nathorn Chaiyakunapruk
  • Kenneth Lee
  • Chayanin Pratoomsoot
  • Huey Chong Yi
  • Aaron Kamauu
  • Richard E. Nelson
  • Mohamed Kamal
چکیده

Outbreaks by Linking PK/PD and Epidemiology via Transmission Dynamic Model: A Novel Approach Patrick Smith, PharmD; Carl Kirkpatrick, PhD; Craig Rayner, PharmD MBA; Keith Nieforth, PharmD; Georgina Dall, PharmD; Stephen Toovey, MD PhD; David Kong, PhD; David Wu, PhD; Nathorn Chaiyakunapruk, PharmD PhD; Kenneth Lee, PhD; Chayanin Pratoomsoot; Huey Chong Yi; Aaron Kamauu, MD MSMPH; Richard E. Nelson, PhD; Mohamed Kamal, PharmD PhD; D3 Medicine, Parsippany, NJ; Pharmacy Practice, Monash University, Parkville, Australia; Pegasus Research, Bottmingen, Switzerland; Monash University, Selangor, Malaysia; Anolinx, Murray, UT; Internal Medicine, University of Utah, Salt Lake City, UT; Roche, New York, NY

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Review of Influenza Surveillance System in the Islamic Republic of Iran: History, Structures and Processes

Background and Objectives: Iran, like most other countries in the world, is always threatened with global epidemics and pandemics of influenza. The purpose of this study was to review the influenza surveillance system in Iran.   Methods: Data of this study were obtained from the surveillance system of the Center for Communicable Disease Control, the review of records, documents, books and pub...

متن کامل

Assessing the use of antiviral treatment to control influenza.

Vaccines are the cornerstone of influenza control policy, but can suffer from several drawbacks. Seasonal influenza vaccines are prone to production problems and low efficacies, while pandemic vaccines are unlikely to be available in time to slow a rapidly spreading global outbreak. Antiviral therapy was found to be beneficial during the influenza A(H1N1)pdm09 pandemic even with limited use; ho...

متن کامل

تغییرات ژنتیکی ویروس و فرار از سامانه ایمنی، چالش‌های پیش‌رو علیه آنفلوآنزا: مقاله مروری

The spread of influenza viruses in multiple bird and mammalian species is a worldwide serious threat to human and animal populations' health and raise major concern for ongoing pandemic in humans. Direct transmission of the avian viruses which have sialic acid specific receptors similar to human influenza viruses are a warning to the emergence of a new mutant strain that is likely to share mole...

متن کامل

Performance Evaluation of Moving Epidemic Method Model in Determining Threshold Levels of Influenza Outbreaks in Iran

Background and Objectives: Timely dection of influenza outbreaks is very important for a better reponse to outbreaks. The aim of this study was to assess the moving epidemic method for determinating influenza outbreak threshold levels in Iran. Methods: The moving epidemic method was applied to the WHO Flunet website data from January 2010 to December 2017 with the aim of determining outbreak...

متن کامل

High Titers of Hemagglutination Inhibition Antibodies against 2009 H1N1 Influenza Virus in Southern Iran

Background: Pandemic flu had at least two waves in Iran. Knowing how many of the general population were already exposed to this infection has a major impact on na-tional preventive measures. As of December 30, 2009, a total of 3672 confirmed cases of human infection with a novel Influenza A (2009 H1N1) virus had been reported in Iran with 140 deaths. Objective: In this study we aim to measure,...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2014